Article
Role of lymph-borne cells in the early stages of scrapie agent dissemination from the skin.
Veterinary immunology and immunopathology - 15 Feb 2006
Gossner Anton, Hunter Nora, Hopkins John
Abstract excerpt
Scrapie is a natural transmissible spongiform encephalopathy (TSE) of sheep, infecting the animal via the gastrointestinal tract or the skin. This project tested the hypotheses that lymph-borne cells (especially dendritic cells) are crucial for the systemic dissemination of the infectious agent from the site of infection in the skin, that PrP genotype affects PrPSC association with dendritic cells and that PrPSC...
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