Article
Soluble mimics of the cytoplasmic face of the human V1-vascular vasopressin receptor bind arrestin2 and calmodulin.
Molecular pharmacology - 1 Jul 2006
Wu Nan, Macion-Dazard Rosemarie, Nithianantham Stanley, Xu Zhen, Hanson Susan M, Vishnivetskiy Sergey A, Gurevich Vsevolod V, Thibonnier Marc, Shoham Menachem
Abstract excerpt
Signal transduction by G protein-coupled receptors (GPCRs) is mediated by interactions between intracellular proteins and exposed motifs on the cytoplasmic face of these receptors. Arrestins bind to GPCRs and modulate receptor function either by interfering with heterotrimeric G protein signaling or by serving as signaling adaptors themselves. Calmodulin interacts with GPCRs triggering a calcium response. We have...
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