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Article

A common polymorphism in the interleukin 8 gene promoter is associated with Clostridium difficile diarrhea.

The American journal of gastroenterology - 1 May 2006

Jiang Zhi-Dong, DuPont Herbert L, Garey Kevin, Price Margaret, Graham Gail, Okhuysen Pablo, Dao-Tran Thanh, LaRocco Mark

Abstract excerpt

OBJECTIVE: Mucosal interleukin 8 (IL-8) and neutrophil recruitment are central to the pathogenesis of Clostridium difficile (CD) toxin-induced diarrhea (CDD). We hypothesized that like other inflammatory mucosal infections, susceptibility to CDD would relate to genetically determined variations in the production of IL-8. METHODS: Fecal IL-8 production and single nucleotide polymorphism (SNP) frequency in the -251...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enterocolitis, Pseudomembranous

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Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 16573784
DOI: 10.1111/j.1572-0241.2006.00482.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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