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Article

Genetic polymorphisms of interleukin 8 and risk of ulcerative colitis in the Chinese population.

Clinica chimica acta; international journal of clinical chemistry - 1 Jul 2009

Li Keshen, Yao Songpo, Liu Shengyuan, Wang Binyou, Mao Dongwei

Abstract excerpt

BACKGROUND: Interleukin-8 (IL-8), a CXC chemokine that recruits and activates inflammatory cells, plays a critical role in the pathogenesis of ulcerative colitis (UC). There are no studies on the association of single nucleotide polymorphisms (SNPs) of the IL-8 gene with the risk of UC. METHODS: All 162 unrelated UC patients and 203 control subjects were analyzed for 5 IL-8 SNPs ((-845 (T/C), -738 (T/A), -353...

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PMID: 19348790
DOI: 10.1016/j.cca.2009.03.053

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