Article
Is the interleukin 8 promoter polymorphism rs4073/-251T >A associated with Clostridium difficile infection?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2014
Miyajima Fabio, Swale Andrew, Zhang J Eunice, Alfirevic Ana, Little Margaret, Beeching Nicholas J, Smith Godfrey, Kolamunnage-Dona Ruwanthi, Pirmohamed Munir
Abstract excerpt
The interleukin 8 gene single-nucleotide polymorphism rs4073/-251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/-251T >A is unlikely to constitute a major risk factor for CDI.
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