Article
A common polymorphism in the interleukin-8 gene promoter is associated with an increased risk for recurrent Clostridium difficile infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Dec 2010
Garey Kevin W, Jiang Zhi-Dong, Ghantoji Shashank, Tam Vincent H, Arora Vaneet, Dupont Herbert L
Abstract excerpt
BACKGROUND: Neutrophil recruitment coordinated by intestinal interleukin (IL)-8 secretion is a key component in the pathogenesis of Clostridium difficile infection (CDI). We hypothesized that a common single-nucleotide polymorphism (SNP) in the -251 region of the IL-8 gene promoter may be predictive of recurrent CDI. METHODS: This was a prospective cohort study of hospitalized adult patients with CDI who were...
Topics
- Aged
- Clostridioides difficile
- Cohort Studies
- Enterocolitis, Pseudomembranous
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Hospitalization
- Humans
- Interleukin-8
- Male
- Middle Aged
- Polymerase Chain Reaction