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Article

The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2005

Lee Wei-Ping, Tai Dar-In, Lan Keng-Hsin, Li Anna Fen-Yau, Hsu Hou-Ching, Lin En-Ju, Lin Yi-Ping, Sheu Meei-Ling, Li Chung-Pin, Chang Full-Young, Chao Yee, Yen Shang-Heu, Lee Shou-Dong

Abstract excerpt

PURPOSE: Persistent interleukin-8 (IL-8) production contributes to chronic inflammation of the stomach. The proinflammatory IL-1beta polymorphisms, which enhance the cytokine production, are associated with increased risk of gastric cancer. The -251A/T polymorphism of the IL-8 promoter is involved in several human diseases. Particularly, the -251A is associated with decreased risk of colorectal cancer. We aimed...

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PMID: 16166417
DOI: 10.1158/1078-0432.CCR-05-0942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population.PMID 16166417Read ↗

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