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Evaluation of PRKAA2 Genetic Variation on Metformin Efficacy as an Initial Therapy Among Drug-Naïve Patients With Type II Diabetes Mellitus

2020-11-24

Abstract excerpt

<h4>Background: </h4> Metformin is the most popular oral antidiabetic agent, which is recommended as initial monotherapy. AMPK is the pivotal target of metformin molecular mechanisms. AMPK subunit a2 (encoded by PRKAA2 ) is a gene contributable to increase type 2 diabetes mellitus (T2DM) risk. This study aimed to evaluate PRKAA2 rs2796498, rs2746342, and rs980799 genetic variations on metformin efficacy. <h4>Metho...

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Literature Corpus work
d2402d98-b248-59db-a8b8-de1b89893598
DOI
10.21203/rs.3.rs-107043/v1
Open publication

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Evaluation of PRKAA2 Genetic Variation on Metformin Efficacy as an Initial Therapy Among Drug-Naïve Patients With Type II Diabetes MellitusDOI 10.21203/rs.3.rs-107043/v1
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