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Article

The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells.

The Journal of biological chemistry - 18 Mar 2005

Ward Diane McVey, Vaughn Michael B, Shiflett Shelly L, White Paul L, Pollock Amanda L, Hill Joshua, Schnegelberger Rachel, Sundquist Wesley I, Kaplan Jerry

Abstract excerpt

We examined the function of LIP5 in mammalian cells, because the yeast homologue Vta1p was recently identified as a protein required for multivesicular body (MVB) formation. LIP5 is predominantly a cytosolic protein. Depletion of LIP5 by small inhibitory RNA (siRNA) does not affect the distribution or morphology of early endosomes, lysosomes, or Golgi but does reduce the degradation of internalized epidermal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15644320
DOI: 10.1074/jbc.M413734200

Genes

CHMP5
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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