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Article

Mammalian VPS45 orchestrates trafficking through the endosomal system

22 Dec 2020

Abstract excerpt

Vacuolar protein sorting 45 homolog (VPS45), a member of the Sec1/Munc18 (SM) family, has been implicated in the regulation of endosomal trafficking. VPS45 deficiency in human patients results in congenital neutropenia, bone marrow fibrosis, and extramedullary renal hematopoiesis. Detailed mechanisms of the VPS45 function are unknown. Here, we show an essential role of mammalian VPS45 in maintaining the...

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PMID: 33512427
DOI: 10.1182/blood.2020006871

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