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Article

A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR.

RNA (New York, N.Y.) - 1 Jun 2007

Yoo Min-Hyuk, Xu Xue-Ming, Turanov Anton A, Carlson Bradley A, Gladyshev Vadim N, Hatfield Dolph L

Abstract excerpt

Selenocysteine insertion into protein in mammalian cells requires RNA elements in the 3'-untranslated regions (3'-UTRs) of selenoprotein genes. The occurrence of these conserved sequences should make selenoproteins particularly amenable for knockdown/knock-in strategies to examine selenoprotein f...

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Identifiers

PMID: 17468436
DOI: 10.1261/rna.533007
PMCID: PMC1869036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17468436-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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