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Article

Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies.

Science translational medicine - 24 Nov 2010

Lanzani Chiara, Citterio Lorena, Glorioso Nicola, Manunta Paolo, Tripodi Grazia, Salvi Erika, Carpini Simona Delli, Ferrandi Mara, Messaggio Elisabetta, Staessen Jan A, Cusi Daniele, Macciardi Fabio, Argiolas Giuseppe, Valentini Giovanni, Ferrari Patrizia, Bianchi Giuseppe

Abstract excerpt

Twenty years of genetic studies have not contributed to improvement in the clinical management of primary arterial hypertension. Genetic heterogeneity, epistatic-environmental-biological interactions, and the pathophysiological complexity of hypertension have hampered the clinical application of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21106941
DOI: 10.1126/scitranslmed.3001814

Genes

ABCB1
ADD1
ADD3
LSS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21106941-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies.PMID 21106941Read ↗

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Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin.Semantic proximity Read ↗

Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.Semantic proximity Read ↗

Genetic variations of tubular sodium reabsorption leading to "primary" hypertension: from gene polymorphism to clinical symptoms.Semantic proximity Read ↗

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