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Article

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis.

Brain research bulletin - 14 Apr 2006

Tajouri Lotti, Martin Virginie, Gasparini Claudia, Ovcaric Micky, Curtain Rob, Lea Rod A, Haupt Larisa M, Csurhes Peter, Pender Michael P, Griffiths Lyn R

Abstract excerpt

Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination. The C677T substitution variant in the methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease. Higher blood levels of homocysteine have also been reported in MS. Thus,...

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Identifiers

PMID: 16564429
DOI: 10.1016/j.brainresbull.2006.01.005

Genes

COMT
MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis.PMID 16564429Read ↗

Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels.Semantic proximity Read ↗

Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia.Semantic proximity Read ↗

No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort.Semantic proximity Read ↗

Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients.Semantic proximity Read ↗

The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion.Semantic proximity Read ↗

The variant methylenetetrahydrofolate reductase c.1298A>C (p.E429A) is associated with multiple sclerosis in a German case-control study.Semantic proximity Read ↗

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Association of methylenetetrahydrofolate reductase gene C677T polymorphism with multiple sclerosis in Turkish patients.Semantic proximity Read ↗

Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population.Semantic proximity Read ↗

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