Article
No association between Parkinson's disease and low-activity alleles of catechol O-methyltransferase.
Biochemical and biophysical research communications - 21 Nov 1996
Hoda F, Nicholl D, Bennett P, Arranz M, Aitchison K J, al-Chalabi A, Kunugi H, Vallada H, Leigh P N, Chaudhuri K R, Collier D A
Abstract excerpt
Idiopathic Parkinson's disease (IPD) is characterised by the loss of pigmented neurones in the substantia nigra, leading to reduced tyrosine hydroxylase activity and depletion of dopamine. Treatments attempt to correct this deficit by the use of levodopa and inhibitors of dopamine metabolising enzymes such as catechol-O-methytransferase (COMT). A common amino-acid polymorphism in COMT, valine-108-methionine,...
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