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Article

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998

Iliopoulos O, Ohh M, Kaelin W G

Abstract excerpt

The von Hippel-Lindau (VHL) gene encodes a protein consisting of 213 amino acid residues with an apparent molecular mass of 30 kDa (pVHL30). Here we show that cells also produce a VHL protein (pVHL19) that appears to arise as a result of internal translation from the second methionine within the VHL ORF. pVHL30 resides primarily in the cytosol, with less amounts found in the nucleus or associated with cell...

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Identifiers

PMID: 9751722
DOI: 10.1073/pnas.95.20.11661
PMCID: PMC21697

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation.PMID 9751722Read ↗

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Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.Semantic proximity Read ↗

Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression.Semantic proximity Read ↗

Proteostasis Modulators Prolong Missense VHL Protein Activity and Halt Tumor ProgressionSemantic proximity Read ↗

Two sides to every story: the HIF-dependent and HIF-independent functions of pVHLSemantic proximity Read ↗

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.Semantic proximity Read ↗

Is the P25L a "real" VHL mutation?Semantic proximity Read ↗

von Hippel-Lindau DiseaseSemantic proximity Read ↗

Identification of a novel duplication mutation in the VHL gene in a large Chinese family with Von Hippel-Lindau (VHL) syndrome.Semantic proximity Read ↗

Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region.Semantic proximity Read ↗

The von Hippel-Lindau gene and protein in tumorigenesis and angiogenesis: a potential target for therapeutic designs.Semantic proximity Read ↗

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