Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Affinity maturation of a single-chain antibody against hepatocellular carcinoma].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 Mar 2006

Lu Xiao-hua, Yang Dong-hua, Zhou Min, Tang Shao-hui

Abstract excerpt

OBJECTIVES: To obtain a single-chain antibody with high affinity against hepatocellular carcinoma (HCC). METHODS: A second single-chain antibody mutant library was established using an error-prone PCR and a phage display. Single-chain antibodies with high affinity for hepatocellular carcinoma were selected using ELISA. RESULTS: The content of the second single-chain antibody mutant library was about 4.5 x 10(7)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neoplasm
Share to Antibody Affinity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antibody Specificity

Share to Carcinoma, Hepatocellular

Share to Immunoglobulin Fragments

Share to Immunoglobulin Variable Region

Share to Liver Neoplasms

Share to Peptide Library

Source

Identifiers

PMID: 16556413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Affinity maturation of a single-chain antibody against hepatocellular carcinoma].PMID 16556413Read ↗

Recombinant polyclonal antibodies for cancer therapySemantic proximity Read ↗

Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCRSemantic proximity Read ↗

Synthetic single-framework antibody library integrated with rapid affinity maturation by VL shufflingSemantic proximity Read ↗

"Breeding" diagnostic antibodies for higher assay performance: a 250-fold affinity-matured antibody mutant targeting a small biomarker.Semantic proximity Read ↗

Improving antibody affinity through in vitro mutagenesis in complementarity determining regionsSemantic proximity Read ↗

Coupling recombinase-mediated cassette exchange with somatic hypermutation for antibody affinity maturation in CHO cells.Semantic proximity Read ↗

[Construction and expression of scFv phage antibody from natural anti-keratin monoclonal antibody 3B4].Semantic proximity Read ↗

Affinity improvement by fine tuning of single-chain variable fragment against aflatoxin B1.Semantic proximity Read ↗

The application of adenine deaminase in antibody affinity maturation.Semantic proximity Read ↗

[Transglutaminase-based antibody-drug conjugation: antibody site-specific mutation and identification].Semantic proximity Read ↗

In vitro evolution of single-chain antibodies using mRNA displaySemantic proximity Read ↗

High efficiency CHO cell display-based antibody maturation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.