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[Transglutaminase-based antibody-drug conjugation: antibody site-specific mutation and identification].

Yao xue xue bao = Acta pharmaceutica Sinica - 1 Mar 2017

Ma Zhao-xiong, Xu Yao, Zhao Hong, Sun Fu-mou, Zhang Xin-rong, Wang Min, Zhang Juan

Abstract excerpt

Transglutaminase (TG) posttranslational modification of antibody permits more precisely conjugating. Based on the amino acid sequence of an anti-CD24 antibody (cG7), this article is aimed to generate a deglycosylated cG7 mutant (cG7Q). Firstly, we introduced additional glutamines at position 297 (N297Q) by site-directed mutagenesis, and then transfected the recombinant plasmids into CHO-s cells...

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PMID: 29979846

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