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Article

High efficiency CHO cell display-based antibody maturation.

Scientific reports - 15 May 2020

Luo Ruiqi, Zhao Yun, Fan Yingjun, An Lili, Jiang Tao, Ma Shaohua, Hang Haiying

Abstract excerpt

Previously, we developed a CHO cell display-based antibody maturation procedure in which an antibody (or other protein) gene of interest was induced to mutate by activation-induced cytidine deaminase (AID) and then form a library by simply proliferating the CHO cells in culture. In this study, we further improved the efficiency of this maturation system by reengineering AID, and optimizing the nucleic acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32415149
DOI: 10.1038/s41598-020-65044-7
PMCID: PMC7229201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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