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Article

A phosphorylation site mutant of Schizosaccharomyces pombe cdc2p fails to promote the metaphase to anaphase transition.

Molecular & general genetics : MGG - 1 Sept 1998

Gould K L, Feoktistova A, Fleig U

Abstract excerpt

The protein kinase cdc2p is a key regulator of the G1-S and G2-M cell cycle transitions in the yeast Schizosaccharomyces pombe. Activation of cdc2p is regulated by its phosphorylation state and by interaction with other proteins. We have analyzed the consequences for cell cycle progression of altering the conserved threonine phosphorylation site, within the activation loop of cdc2p, to glutamic acid. This mutant,...

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PMID: 9790601
DOI: 10.1007/s004380050834

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