Article
T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue.
The Plant cell - 1 Mar 2007
Dissmeyer Nico, Nowack Moritz K, Pusch Stefan, Stals Hilde, Inzé Dirk, Grini Paul E, Schnittger Arp
Abstract excerpt
As in other eukaryotes, progression through the cell cycle in plants is governed by cyclin-dependent kinases. Phosphorylation of a canonical Thr residue in the T-loop of the kinases is required for high enzyme activity in animals and yeast. We show that the Arabidopsis thaliana Cdc2(+)/Cdc28 homolog CDKA;1 is also phosphorylated in the T-loop and that phosphorylation at the conserved Thr-161 residue is essential...
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