Article
Dephosphorylation of threonine 169 of Cdc28 is not required for exit from mitosis but may be necessary for start in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Aug 1996
Lim H H, Loy C J, Zaman S, Surana U
Abstract excerpt
Entry into mitosis requires activation of cdc2 kinase brought on by its association with cyclin B, phosphorylation of the conserved threonine (Thr-167 in Schizosaccharomyces pombe) in the T loop, and dephosphorylation of the tyrosine residue at position 15. Exit from mitosis, on the other hand, i...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Cyclin-Dependent Kinases
- Cyclins
- DNA Primers
- Mitosis
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phosphoprotein Phosphatases
- Phosphothreonine
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Signal Transduction
- Structure-Activity Relationship