Article
Cytotoxic and mutagenic effect of UV, ethylnitrosourea and (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo [a]pyrene in diploid human T lymphocytes in culture: comparison with fibroblasts.
Mutagenesis - 1 Sept 1990
Norimura T, Maher V M, McCormick J J
Abstract excerpt
The cytotoxic and mutagenic effects of a series of carcinogenic mutagens in human peripheral blood T cells exposed in culture were determined and compared with results obtained previously with diploid human skin fibroblasts. The mutagens studied were: ethylnitrosourea (ENU), (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) and UV (254 nm) radiation. Resistance to...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Adult
- Cell Division
- Cell Survival
- Cells, Cultured
- Drug Resistance
- Ethylnitrosourea
- Fibroblasts
- Humans
- Mutagenicity Tests