Article
Innate immune recognition of flagellin limits systemic persistence of Brucella.
Cellular microbiology - 1 Jun 2013
Terwagne Matthieu, Ferooz Jonathan, Rolán Hortensia G, Sun Yao-Hui, Atluri Vidya, Xavier Mariana N, Franchi Luigi, Núñez Gabriel, Legrand Thomas, Flavell Richard A, De Bolle Xavier, Letesson Jean-Jacques, Tsolis Renée M
Abstract excerpt
Brucella are facultative intracellular bacteria that cause chronic infections by limiting innate immune recognition. It is currently unknown whether Brucella FliC flagellin, the monomeric subunit of flagellar filament, is sensed by the host during infection. Here, we used two mutants of Brucella melitensis, either lacking or overexpressing flagellin, to show that FliC hinders bacterial replication in vivo. The...
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