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Article

Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.

Frontiers in immunology - 1 Jan 2020

Holzapfel Marion, Bonhomme Delphine, Cagliero Julie, Vernel-Pauillac Frédérique, Fanton d'Andon Martine, Bortolussi Sophia, Fiette Laurence, Goarant Cyrille, Wunder Elsio A, Picardeau Mathieu, Ko Albert I, Werling Dirk, Matsui Mariko, Boneca Ivo G, Werts Catherine

Abstract excerpt

Leptospira (L.) interrogans are invasive bacteria responsible for leptospirosis, a worldwide zoonosis. They possess two periplasmic endoflagellae that allow their motility. L. interrogans are stealth pathogens that escape the innate immune recognition of the NOD-like receptors NOD1/2, and the human Toll-like receptor (TLR)4, which senses peptidoglycan and lipopolysaccharide (LPS), respectively. TLR5 is another...

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Identifiers

PMID: 32849665
DOI: 10.3389/fimmu.2020.02007
PMCID: PMC7431986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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