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Article

Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.

Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006

Wani Manzoor A, Haynes Lynn D, Kim Jonghan, Bronson C L, Chaudhury Chaity, Mohanty Sudhasri, Waldmann Thomas A, Robinson John M, Anderson Clark L

Abstract excerpt

Two siblings, products of a consanguineous marriage, were markedly deficient in both albumin and IgG because of rapid degradation of these proteins, suggesting a lack of the neonatal Fc receptor, FcRn. FcRn is a heterodimeric receptor composed of a nonclassical MHC class I alpha-chain and beta(2)-microglobulin (beta(2)m) that binds two ligands, IgG and albumin, and extends the catabolic half-lives of both. Eight...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16549777
DOI: 10.1073/pnas.0600548103
PMCID: PMC1458798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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