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Article

Generation and analysis of proline mutants in protein G.

Protein engineering, design & selection : PEDS - 1 Jun 2006

Choi Eun Jung, Mayo Stephen L

Abstract excerpt

The pyrrolidine ring of the amino acid proline reduces the conformational freedom of the protein backbone in its unfolded form and thus enhances protein stability. The strategy of inserting proline into regions of the protein where it does not perturb the structure has been utilized to stabilize many different proteins including enzymes. However, most of these efforts have been based on trial and error, rather...

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PMID: 16549401
DOI: 10.1093/protein/gzl007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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