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Article

Alanine and proline content modulate global sensitivity to discrete perturbations in disordered proteins.

Proteins - 1 Dec 2014

Perez Romel B, Tischer Alexander, Auton Matthew, Whitten Steven T

Abstract excerpt

Molecular transduction of biological signals is understood primarily in terms of the cooperative structural transitions of protein macromolecules, providing a mechanism through which discrete local structure perturbations affect global macromolecular properties. The recognition that proteins lacking tertiary stability, commonly referred to as intrinsically disordered proteins (IDPs), mediate key signaling...

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Identifiers

PMID: 25244701
DOI: 10.1002/prot.24692
PMCID: PMC4237723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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