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Article

Structure of a protein G helix variant suggests the importance of helix propensity and helix dipole interactions in protein design.

Protein science : a publication of the Protein Society - 1 Jul 2000

Strop P, Marinescu A M, Mayo S L

Abstract excerpt

Six helix surface positions of protein G (Gbeta1) were redesigned using a computational protein design algorithm, resulting in the five fold mutant Gbeta1m2. Gbeta1m2 is well folded with a circular dichroism spectrum nearly identical to that of Gbeta1, and a melting temperature of 91 degrees C, approximately 6 degrees C higher than that of Gbeta1. The crystal structure of Gbeta1m2 was solved to 2.0 A resolution...

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Identifiers

PMID: 10933505
DOI: 10.1110/ps.9.7.1391
PMCID: PMC2144681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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