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Article

Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice.

Oncogene - 5 Jul 2001

Ludwig T, Fisher P, Murty V, Efstratiadis A

Abstract excerpt

Cre-mediated deletion of exons 3 and 4 of the mouse Brca2 gene occurring specifically in mammary epithelial cells of conditional female mutants carrying a combination of loxP-modified and null Brca2 alleles resulted in a high incidence (77%) of breast tumors that were often palpable and developed in one or more glands after long latency (time for median tumor-free survival of approximately 1.4 years; total of 40...

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Identifiers

PMID: 11494122
DOI: 10.1038/sj.onc.1204512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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