Article
Thymic lymphomas in mice with a truncating mutation in Brca2.
Cancer research - 1 Apr 1998
Friedman L S, Thistlethwaite F C, Patel K J, Yu V P, Lee H, Venkitaraman A R, Abel K J, Carlton M B, Hunter S M, Colledge W H, Evans M J, Ponder B A
Abstract excerpt
Inherited mutations in the BRCA2 gene predispose women to breast and ovarian cancer. We created a mutation in the mouse Brca2 gene that terminates translation in exon 11 at 45% of the normal transcript length. Ninety % of Brca2(tm1Cam) homozygous mutant mice die prenatally or perinatally. The loc...
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