An assembly defect as a result of an attenuating mutation in the capsid proteins of the poliovirus type 3 vaccine strain.

doi:10.1128/JVI.65.10.5225-5231.1991

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Article

An assembly defect as a result of an attenuating mutation in the capsid proteins of the poliovirus type 3 vaccine strain.

Journal of virology - 1 Oct 1991

Macadam A J, Ferguson G, Arnold C, Minor P D

Abstract excerpt

The molecular basis of the temperature-sensitive (ts) phenotype of P3/Sabin, the type 3 vaccine strain of poliovirus, was investigated in light of the known correlation between ts and attenuation phenotypes. A phenylalanine at residue 91 of the capsid protein VP3 was a major determinant of both p...

Topics

Capsid
Cell Line
Centrifugation, Density Gradient
Humans
Kinetics
Mutation
Phenotype
Poliovirus
Poliovirus Vaccine, Oral
RNA, Viral
Temperature
Vaccines, Attenuated

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