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Article

Cytotoxic and immune-mediated killing of human colorectal cancer by reovirus-loaded blood and liver mononuclear cells.

International journal of cancer - 15 May 2013

Adair Robert A, Scott Karen J, Fraser Sheila, Errington-Mais Fiona, Pandha Hardev, Coffey Matt, Selby Peter, Cook Graham P, Vile Richard, Harrington Kevin J, Toogood Giles, Melcher Alan A

Abstract excerpt

Reovirus is a promising oncolytic virus, acting by both direct and immune-mediated mechanisms, although its potential may be limited by inactivation after systemic delivery. Our study addressed whether systemically delivered reovirus might be shielded from neutralising antibodies by cell carriage and whether virus-loaded blood or hepatic innate immune effector cells become activated to kill colorectal cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

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Source

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Identifiers

PMID: 23114986
DOI: 10.1002/ijc.27918
PMCID: PMC3891508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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