Article
Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan.
Oncotarget - 15 May 2014
Maitra Radhashree, Seetharam Raviraja, Tesfa Lydia, Augustine Titto A, Klampfer Lidija, Coffey Matthew C, Mariadason John M, Goel Sanjay
Abstract excerpt
Reovirus is a double stranded RNA virus, with an intrinsic preference for replication in KRAS mutant cells. As 45% of human colorectal cancers (CRC) harbor KRAS mutations, we sought to investigate its efficacy in KRAS mutant CRC cells, and examine its impact in combination with the topoisimerase-1 inhibitor, irinotecan. Reovirus efficacy was examined in the KRAS mutant HCT116, and the isogenic KRAS WT Hke3 cell...
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