Article
Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12.
Molecular oncology - 1 Jun 2011
Malvicini Mariana, Ingolotti Mariana, Piccioni Flavia, Garcia Mariana, Bayo Juan, Atorrasagasti Catalina, Alaniz Laura, Aquino Jorge B, Espinoza Jaime A, Gidekel Manuel, Scharovsky O Graciela, Matar Pablo, Mazzolini Guillermo
Abstract excerpt
Immunotherapy-based strategies for gastrointestinal carcinomas (GIC) have been exploited so far, but these approaches have to face strong mechanisms of immune escape induced by tumours. We previously demonstrated that sub-therapeutic doses of an adenovirus expressing IL-12 genes (AdIL-12) mediated a potent antitumour effect against subcutaneous (s.c.) colorectal carcinomas (CRC) in mice pre-treated with low doses...
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