Article
Direct evidence that PKCα positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesiveness.
The Journal of pathology - 1 Jul 2012
Thomason Helen A, Cooper Nichola H, Ansell David M, Chiu Maybo, Merrit Anita J, Hardman Matthew J, Garrod David R
Abstract excerpt
Non-healing wounds cause considerable patient morbidity and represent a significant economic burden. Central to wound repair is re-epithelialization, a crucial process involving the modulation of cell adhesion to allow keratinocyte migration to cover the exposed underlying tissues. The cellular mechanisms regulating the earliest stages of re-epithelialization are unclear. We present the first direct evidence that...
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