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Prostaglandins regulate invasive, collective border cell migration

20 May 2020

Abstract excerpt

cyclooxygenase-like enzyme responsible for PG synthesis. Loss of Pxt results in both delayed border cell migration and elongated clusters, whereas somatic Pxt knockdown causes delayed migration and compacted clusters. These findings suggest PGs act in both the border cells and nurse cells, the substrate on which the border cells migrate. As PGs regulate the actin bundler Fascin, and Fascin is required for on-time...

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PMID: 32432969
DOI: 10.1091/mbc.e19-10-0578

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