Article
The alpha-synuclein gene in multiple system atrophy.
Journal of neurology, neurosurgery, and psychiatry - 1 Apr 2006
Ozawa T, Healy D G, Abou-Sleiman P M, Ahmadi K R, Quinn N, Lees A J, Shaw K, Wullner U, Berciano J, Moller J C, Kamm C, Burk K, Josephs K A, Barone P, Tolosa E, Goldstein D B, Wenning G, Geser F, Holton J L, Gasser T, Revesz T, Wood N W
Abstract excerpt
BACKGROUND: The formation of alpha-synuclein aggregates may be a critical event in the pathogenesis of multiple system atrophy (MSA). However, the role of this gene in the aetiology of MSA is unknown and untested. METHOD: The linkage disequilibrium (LD) structure of the alpha-synuclein gene was established and LD patterns were used to identify a set of tagging single nucleotide polymorphisms (SNPs) that represent...
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