Article
UCHL-1 gene in multiple system atrophy: a haplotype tagging approach.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2005
Healy Daniel G, Abou-Sleiman Patrick M, Quinn Niall, Ahmadi Kourosh R, Ozawa Tetsutaro, Kamm Christoph, Wullner Ullrich, Oertel Wolfgang H, Burk Katrin, Dupont Erik, Pellecchia Maria T, Tolosa Eduardo, Gasser Thomas, Holton Janice L, Revesz Tamas, Goldstein David B, Lees Andrew J, Wood Nicholas W
Abstract excerpt
To date, the etiology of multiple system atrophy (MSA) has proved impenetrable. We investigated the role of genetic variation in the UCHL-1 gene in MSA and looked for the presence of disease susceptibility alleles. We determined the linkage disequilibrium structure of the gene and employed a haplotype tagging strategy with power to represent 95% of the haplotype diversity. This approach was performed using a set...
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