Article
Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits.
The Journal of biological chemistry - 31 Dec 2004
Galani Kyriaki, Nissan T Amar, Petfalski Elisabeth, Tollervey David, Hurt Ed
Abstract excerpt
Rea1, the largest predicted protein in the yeast genome, is a member of the AAA(+) family of ATPases and is associated with pre-60 S ribosomes. Here we report that Rea1 is required for maturation and nuclear export of the pre-60 S subunit. Rea1 exhibits a predominantly nucleoplasmic localization and is present in a late pre-60 S particle together with members of the Rix1 complex. To study the role of Rea1 in...
Topics
- ATP-Binding Cassette Transporters
- ATPases Associated with Diverse Cellular Activities
- Adenosine Triphosphatases
- Alleles
- Blotting, Northern
- Blotting, Western
- Cell Nucleus
- Cytoplasm
- DNA, Ribosomal Spacer
- Genes, Reporter