NSR1 is required for pre-rRNA processing and for the proper maintenance of steady-state levels of ribosomal subunits.

doi:10.1128/mcb.12.9.3865-3871.1992

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Article

NSR1 is required for pre-rRNA processing and for the proper maintenance of steady-state levels of ribosomal subunits.

Molecular and cellular biology - 1 Sept 1992

Lee W C, Zabetakis D, Mélèse T

Abstract excerpt

NSR1 is a yeast nuclear localization sequence-binding protein showing striking similarity in its domain structure to nucleolin. Cells lacking NSR1 are viable but have a severe growth defect. We show here that NSR1, like nucleolin, is involved in ribosome biogenesis. The nsr1 mutant is deficient i...

Topics

Fungal Proteins
Mutation
Nuclear Proteins
Paromomycin
RNA Processing, Post-Transcriptional
RNA, Ribosomal
RNA-Binding Proteins
Ribosomes
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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