Article
Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: Studies ofCDKN2A and other genes of the pRB pathway
1 Oct 1999
Abstract excerpt
Malignant peripheral nerve sheath tumors (MPNSTs) are frequently associated with the disease neurofibromatosis type 1. Only few recurrent cytogenetic changes have been reported, including rearrangements of the short arm of chromosome 9. By fluorescence in situ hybridization with a centromere 9 probe, and by allelic imbalance studies with seven 9p21-23 markers in nine familial and three sporadic MPNSTs, we found...
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