Article
Inflammatory cytokine gene polymorphisms, nonsteroidal anti-inflammatory drug use, and risk of adenoma polyp recurrence in the polyp prevention trial.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2006
Sansbury Leah B, Bergen Andrew W, Wanke Kay L, Yu Binbing, Caporaso Neil E, Chatterjee Nilanjan, Ratnasinghe Luke, Schatzkin Arthur, Lehman Teresa A, Kalidindi Aravind, Modali Ramakrishna, Lanza Elaine
Abstract excerpt
BACKGROUND: Pro- and anti-inflammatory cytokine genes may be important in the maintenance and progression of colorectal cancer. It is possible that single-nucleotide polymorphisms in inflammatory genes may play a role in chronic colonic inflammation and development of colorectal adenomas. Furthermore, common variants in cytokine genes may modify the anti-inflammatory effect of nonsteroidal anti-inflammatory drugs...
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