Article
Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer susceptibility.
International journal of cancer - 1 Oct 2007
Barwell Julian, Pangon Laurent, Georgiou Anne, Kesterton Ian, Langman Caroline, Arden-Jones Audrey, Bancroft Elizabeth, Salmon Ashi, Locke Imogen, Kote-Jarai Zsofia, Morris Joanna R, Solomon Ellen, Berg Jonathan, Docherty Zoe, Camplejohn Richard, Eeles Rosalind, Hodgson Shirley V
Abstract excerpt
There is conflicting evidence as to whether individuals who are heterozygous for germ-line BRCA1 or BRCA2 mutations have an altered phenotypic cellular response to irradiation. To investigate this, chromosome breakage and apoptotic response were measured after irradiation in peripheral blood lymphocytes from 26 BRCA1 and 18 BRCA2 mutation carriers without diagnosed breast cancer, and 38 unaffected age, ethnically...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.