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Article

SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons.

Proceedings of the National Academy of Sciences of the United States of America - 21 Mar 2006

Rumbaugh Gavin, Adams J Paige, Kim Jee H, Huganir Richard L

Abstract excerpt

Silent synapses, or excitatory synapses that lack functional alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. Here, we report that SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical...

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Source

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Identifiers

PMID: 16537406
DOI: 10.1073/pnas.0600084103
PMCID: PMC1450173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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