Article

Human <i>SYNGAP1</i> Regulates the Development of Neuronal Activity by Controlling Dendritic and Synaptic Maturation

2020-06-03

Abstract excerpt

SYNGAP1 is a major genetic risk factor for global developmental delay, autism spectrum disorder, and epileptic encephalopathy. De novo loss-of-function variants in this gene cause a neurodevelopmental disorder defined by cognitive impairment, social-communication disorder, and early-onset seizures. Cell biological studies in mouse and rat neurons have shown that Syngap1 regulates developing excitatory synapse st...

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Literature Corpus work: 4e2c68c0-04d3-5f71-ae1b-8b30b4992f8e
DOI: 10.1101/2020.06.01.127613

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