Article
Common European mitochondrial haplogroups in the risk for psoriasis and psoriatic arthritis.
Genetic testing and molecular biomarkers - 1 Jun 2012
Coto-Segura Pablo, Santos-Juanes Jorge, Gómez Juan, Alvarez Victoria, Díaz Marta, Alonso Belén, Corao Ana I, Coto Eliecer
Abstract excerpt
Mitochondrial dysfunction could contribute to the pathogenesis of psoriasis (Ps) and Ps-arthritis (PsA). Several common mtDNA polymorphisms/haplogroups have been linked to differences in the production of reactive oxygen species and mitochondrial oxidative damage. To test the hypothesis of an association between mtDNA variants and Ps/PsA, we studied the single-nucleotide polymorphisms that define the common...
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