Article
Highly specific gene silencing by artificial microRNAs in Arabidopsis.
The Plant cell - 1 May 2006
Schwab Rebecca, Ossowski Stephan, Riester Markus, Warthmann Norman, Weigel Detlef
Abstract excerpt
Plant microRNAs (miRNAs) affect only a small number of targets with high sequence complementarity, while animal miRNAs usually have hundreds of targets with limited complementarity. We used artificial miRNAs (amiRNAs) to determine whether the narrow action spectrum of natural plant miRNAs reflects only intrinsic properties of the plant miRNA machinery or whether it is also due to past selection against natural...
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