Article
A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis.
The Plant cell - 1 Aug 2013
Hauser Felix, Chen Wenxiao, Deinlein Ulrich, Chang Kenneth, Ossowski Stephan, Fitz Joffrey, Hannon Gregory J, Schroeder Julian I
Abstract excerpt
Traditional forward genetic screens are limited in the identification of homologous genes with overlapping functions. Here, we report the analyses and assembly of genome-wide protein family definitions that comprise the largest estimate for the potentially redundant gene space in Arabidopsis thaliana. On this basis, a computational design of genome-wide family-specific artificial microRNAs (amiRNAs) was performed...
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