Article
Specific effects of microRNAs on the plant transcriptome.
Developmental cell - 1 Apr 2005
Schwab Rebecca, Palatnik Javier F, Riester Markus, Schommer Carla, Schmid Markus, Weigel Detlef
Abstract excerpt
Most plant microRNAs (miRNAs) have perfect or near-perfect complementarity with their targets. This is consistent with their primary mode of action being cleavage of target mRNAs, similar to that induced by perfectly complementary small interfering RNAs (siRNAs). However, there are natural targets with up to five mismatches. Furthermore, artificial siRNAs can have substantial effects on so-called off-targets, to...
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