Cytoplasmic localization of a mutant M(r) 160,000 topoisomerase II alpha is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line.

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Article

Cytoplasmic localization of a mutant M(r) 160,000 topoisomerase II alpha is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line.

Cancer research - 15 May 1995

Mirski S E, Cole S P

Abstract excerpt

Many clinically important antineoplastic agents exert their cytotoxicity through interaction with the M(r) 170,000 topoisomerase II alpha, an essential nuclear enzyme. Resistance to these agents has been associated frequently with either a decrease in the levels of topoisomerase II alpha or a qualitative change that alters the interaction of this enzyme with a drug or DNA. Using a VP-16-selected lung cancer cell...

Topics

Base Sequence
Blotting, Northern
Carcinoma, Small Cell
Cytoplasm
DNA Topoisomerases, Type II
Drug Resistance
Humans
Isoenzymes
Lung Neoplasms
Molecular Sequence Data
Molecular Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Proteins

Polymerase Chain Reaction

RNA, Messenger

Sequence Deletion

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7743513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7743513-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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